- A. J. Davis Family Collection, 1874/2007, bulk 1874/19078
- Adam Finch Collection, 1891/19331
- Adam T. Finch Papers, 1895/19261
- Adin B. Underwood Papers, 1861/19261
- Alexander Farish Robertson Papers, 1867/19319
- Alexander McNutt Glasgow Family Papers, 1823/19036
- Alleghany Chapter, National Society of the Daughters of the American Revolution Records, 1890/20222
- Antoine Gaujot and Julien E. Gaujot Papers, 1840/19991
- Arthur M. Squires Papers, 1888/1987, bulk 1940/19875
- Attorney's Suit and Collection Record, 1896/19291
- Augustus Smith Family Collection, 1864/19261
- Bailey-Law Collection, 1825/19717
- Baldwin Family Letters, 1861/18971
- Bank of Blacksburg Minute Book, 1892/19031
- Baughman Family Papers, 1837/19686