- Charles F. McKenna Collection, 1861/19984
- Charles W. Crush Collection, 1796/19786
- Charles W. Hardin Collection, 1847/18831
- Charles Walls Collection, 1882/20032
- Charles Willis Cassell Family Papers, 1883/195014
- Charlton Family Papers, 1853/19583
- Christian Hook Diary, 1864/19251
- Christiansburg Presbyterian Church Minute Book, 1869/18972
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19914
- Civil War Scrapbook, 1864/19162
- Civil War Small Manuscripts Collection, 1861/19962
- Claudius Lee Papers, 1887/19541
- Clifford-Wysor Collection, 1852/19585
- Corps of Cadets [Virginia Argicultural and Mechanical College] Duty Roster, 18901
- Craft Family Collection, 1861/19191