- Alabama Great Southern Railroad Company Agreements, 1887/18901
- Alexander Von Humboldt Portrait Print, 1855/18901
- Archer Lawrie Sheet Music Collection, 1879/19352
- Bailey-Law Collection, 1825/197113
- Battle of Cedar Creek Print, 18901
- Black, Kent, and Apperson Family Papers, 1779/19841
- Brown Family Papers, 1825/1965, bulk 1850/18941
- Buckhorn Coal Company Records, 1880/19613
- C. B. Anderson Records, 1884/19101
- Christiansburg Presbyterian Church Minute Book, 1869/18971
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19912
- Culinary Ephemera Collection1
- Dickinson Family Papers, 1871/19311
- George J. Schmutz Papers, 1868/19262
- George Robert Sibold Collection, 1890/19562