- Alexander Lockhart Nelson papers, 1848/19021
- Anderson Family papers, 1755/19581
- Cabinet Photograph of Lexington, Virginia, 1880/18951
- Campbell Family Papers, 1843/19501
- Charles Manson Crutchfield Collection of Memorabilia, 1882/1914, bulk 1880/18891
- Collection of Photographs of Lexington, Va., 1857/19691
- David C. Irwin Collection, 1869/1937, bulk 1887/19371
- Edmondson Family Papers, 1861/19041
- Fix Family Papers, 1830/19241
- Graham Philanthropic Society records, 1809/19421
- Jackson Memorial Association Minute Book, 1883/19251
- Legal Documents, 1742/18951
- Lexington Presbyterian Church collection, 1824/1927, bulk 1877/19271
- Lexington, Virginia, 1818/19912
- Money, 1840/18961