- Adam Empie Papers, 1811/2004, bulk 1811/18502
- Adams Papers, 1782/18901
- Adin B. Underwood Papers,, 1861/19261
- Administration records collection, 1776/197622
- Admiral John Randolph Tucker Papers, 1865/18971
- African American Family Photographs, 1880/19601
- African American man tintype portrait, 1865/19001
- Alabama Collection, 1823/18931
- Albert C. Swindler Papers, 1862/1929, bulk 1862/18641
- Albert Frederick Wilson papers, 1840/19342
- Albert P. Bourland Letter, 18851
- Albert R. Gallatin papers, 1795/18281
- Alderman family papers, 1779/19616
- Alexander Brown Papers (I), 1815/19107
- Alexander Brown Papers (II), 1748/190013