- A. W. Houston certificate, 18832
- Abraham Lincoln Collection, 1860/19651
- Ackerly Family Papers4
- Administration records collection, 1776/197623
- Advertisement Trade Card for "Quignon-Rombach", 1880/19201
- African and African American photograph collection, 1850/19451
- Alan R. Shirkey photograph collection, 1877/19171
- Alexander Lockhart Nelson papers, 1848/19021
- Alexander Sterrett Paxton Papers, 1858/1959, bulk 1861/18652
- Alexander, Fultz, and Willson Families Collection, 1770/19701
- Alfred Leyburn Papers, 1823/1899, bulk 1830/18391
- Almanac collection, 1850/19091
- Alphin Family Photographs, 1870/19301
- American Civil War collection, 1860/18953
- Anderson Family papers, 1755/195816