- Ruffner Family Association Collection, 1811/2014, bulk 1999/20145
- Bugg Family Collection., 1876/19574
- Dabney Lancaster and Lancaster Family Records, 1848/19743
- Harwood Family Collection, 1806/19833
- Paulett Family Business Records, 1877/19293
- Anne Atkinson Chamberlayne Collection., 1742/19632
- Commencement Programs Collection, 1863/20212
- Dr. Wayne McWee Historical Newspapers, 1863/19622
- Elizabeth Burger Jackson Collection, 1950/20061
- James Elliott Walmsley Collection, 1810/19391
- Katherine Courtenay Johnston Collection, 1829/19461
- Mattoon Family Collection, 1870/19661
- Pi Gamma Mu Collection, 1818/19701
- Planters Bank President Portraits, 1870/19051
- Richard Couture Papers, 1860/20031