- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19286
- Cleveland Family Papers, 1880/19583
- Copp's Schoolhouse Notebook and Ledger, 1867/19083
- Cushing Family Papers, 1843/18946
- Daisy Bacon Papers, 1857/19862
- Davis, Kline, and Hutton Family papers, 1816/19772
- Dudley and Rexrode Family Papers, 1873/20055
- Eldon Bowman collection of Bowman family papers, 1797/201911
- Elliott Guthrie Fishburne Papers, 1875/18952
- Floral autograph albums, 1850/18912
- Gallaher and Briscoe Family Confederate Papers, 1858/19252
- Garber and Logan family papers, 1846/19491
- George M. Neese papers, 1859/194614
- George W. Kemper Jr. Medical Ledger, 1857/1892, bulk 1861/18683
- Gordon W. Miller Collection on Gabriel Thomas Barbee, 1787/20052