- Alexandria History Collection (MS240), 1767/20081
- Alexandria Library Company Records (MS002), 1794/20071
- Alexandria Scrapbook Collection (MS003), 1830/18931
- Alexandria, Virginia City Records (MS019), 1750/1983, bulk 1825/18751
- Armistead Boothe Papers (MS164), 1803/19901
- Boush/Asher Family Collection (MS234), 1856/19491
- Cazenove Family Papers (MS212), 1786/19701
- Chapman Family Collection (MS274), 1828/19631
- Charles L. Sampson Collection (MS126), 1841/19861
- Daniel O'Sullivan Collection (MS141), 1850/19121
- Eleanor Lee Templeman Collection (MS061), 1810/19901
- Esther Holliday Green Collection (MS073), 1859/19821
- Florence Davidson Collection (MS318), 1856/19831
- Gilbert J. Cox (MS261), 1838/19311
- Helen Norris Cummings Papers (MS072), 1865/19491