- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/197448
- John Tyler, Jr. Papers, 1800/192847
- Benjamin Stoddert Ewell Papers, 1784/1934, bulk 1830/189246
- Jim Comstock, Newspaper Editor and Collector, Papers, 1650/2003, bulk 1850/199544
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/188742
- Hampshire County (W. Va.) Court Records and Miscellaneous Papers, 1736/194942
- Blow Family Papers, 1613/1960, bulk 1770/187540
- Gustavus Richard "Brown" Horner papers, 1820/189239
- Cocke Family Papers, 1725-193938
- Cynthia Beverley Tucker Washington Coleman Papers, 1834/192838
- Harrisonburg-Rockingham Historical Society Collection, 1740/195038
- McGavock Family Papers, 1760/188837
- Mildred Hassler Layman, Family and Genealogy Papers, 1750/195237
- Galt Papers (I), 1745/189236
- Warner T. Jones Papers, 1818/189136