- Anne Atkinson Chamberlayne Collection., 1742/19631
- Bugg Family Collection., 1876/19573
- Commencement Programs Collection, 1863/20212
- Dabney Lancaster and Lancaster Family Records, 1848/197411
- Dr. Wayne McWee Historical Newspapers, 1863/19622
- Harwood Family Collection, 1806/19833
- James Elliott Walmsley Collection, 1810/19391
- Katherine Courtenay Johnston Collection, 1829/19461
- Pi Gamma Mu Collection, 1818/19704
- Richard Couture Papers, 1860/20031
- Robert C. Anderson - Plantation Records, 1841/18711
- Rosemary Sprague Collection, 1862/19911
- Ruffner Family Association Collection, 1811/2014, bulk 1999/20145
- White Family Correspondence, 1844/18644