- Edmondson Family Papers, 1861/19041
- Edson J. Harkness Papers, 1827/18651
- Edwin L. Dooley, Jr. Collection, 1860/18701
- Elisha Franklin Paxton papers, 1808/1981, bulk 1853/18634
- Ellinor Porcher Gadsden Papers, 1839/19754
- Engraving of General Wade Hampton, 1861/18751
- Fix Family Papers, 1830/19242
- Francis McFarland Papers, 1815/18711
- Francis P. Gaines Papers, 1803/19791
- Francis Wilkinson Pickens collection, 1826/18652
- Franklin Society and Library Company collection, 1838/19711
- Franklin Society records, 1801/189111
- Friendship album, 1846/18832
- George A. Baxter Family papers, 1797/191824
- George Washington collection, 1775/19491