- Collection of Photographs of Lexington, Va., 1857/19691
- Collection of U. S. House of Representatives printed documents about prohibition, 1808/19301
- Contracts for the hiring of enslaved persons by the William Ackerly estate, 1860/18642
- Copy of an ambrotype photograph of George Lewis Dull, 1861/18641
- Cornelia Peake McDonald Diary, 1861/18651
- Cralle and Hurt Family Papers, 1801/20053
- David Ballenger Correspondence, 1858/18881
- David Flavel Jamison papers, 1860/18645
- David Lawrence Hopkins Papers, 1861/18651
- Davidson Family Papers, 1830/19154
- Dillon Family Papers, 1805/19445
- Dr. William S. Plumer manuscripts, 1841/18672
- Dunlap Family Papers, 1830/18785
- E. Steadman Financial Records, 1861/18651
- Edith Funkhouser Major photograph collection, 1860/19372