- Baer Family Papers, 1744/19291
- Bank of Rockbridge Currency and Lexington Lottery Ticket collection, 1803/18622
- Barbara Cary Johnston Willard Scrapbook, 1800/20061
- Ben Benson Collection, 1789/20151
- Blain Family papers, 1861/19052
- Board of Trustees records, 1774/19666
- Boswell Mercantile Ledger, 1855/18611
- Brady Family Papers, 1750/19801
- Breckinridge Family Papers, 1850/18831
- Brick Company Ledger, 1857/18621
- Brooks Family Papers, 1841/18841
- Campbell Family Papers, 1843/19503
- Carleton Family Collection, 1830/19501
- Christopher A. Dorrance collection, 1750/20001
- Collection of Images Related to Stonewall Jackson, 1861/18751