- Cocke Family Papers, 1725-1939253
- Early Records of the Mount Vernon Ladies' Association, 1853/1951, bulk 1853/1875130
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/1887104
- Carter Family Papers, 1667/1862, bulk 1792/186183
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190079
- Tyler Family Papers, Group D, 1939/195168
- Historic newspapers collection, 1757/195760
- Monongalia County (W. Va.) Court Records and Miscellaneous Papers, 1774/195447
- Galt Papers (I), 1745/189243
- Appalachian Prints Collection, 1839/2010, bulk 1859/190942
- John Augustine Washington III and family papers, 1789/199434
- Webb-Prentis Family Papers
1770-190834
- Haymond Family Papers, 1783/1867, bulk 1825/186732
- Myers-Burrage-Graham Papers (I) Group C, 1833/196232
- West Virginia Land Grants Records, 1748/191232