- E. H. Hook Diary, 1820/18712
- E. L. Mathers and Max Mathers, Compilers, Monongalia County Scrapbook, 1838/19511
- Earhart Family Papers, 1788/19285
- Earl Gregg Swem Genealogy Collection, 1719/19826
- Earl L. Core (1902-1984) Papers, 1756/198515
- Earl L. Core, Collector, Papers, 1840/19271
- Early Records of the Mount Vernon Ladies' Association, 1853/1951, bulk 1853/187516
- Easton-Avery Community History, 1769/19271
- Ebenezer Church of Barbour County, Membership Records, 1836/19211
- Ebenezer Dickey Junkin Scrapbook, 1853/18561
- Edgar E. MacDonald papers, 1933/19931
- Edgar Woods Notebook, 1851/18712
- Edgerly Pierson and Sons Ledgers, 1835/18763
- Edith Moore Sprouse Papers (MS313), 1960/20031
- Edmonds Family Papers, 1790/18711