- Bailey-Law Collection, 1825/19711
- Baughman Family Papers, 1837/19681
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/19984
- Black, Kent, and Apperson Family Papers, 1779/19846
- Charles W. Crush Collection, 1796/19781
- Dickson Family Papers, 1769/19243
- Dillard-Larkin Family Papers, 1809/19553
- Earhart Family Papers, 1788/19281
- Henry H. Hill Collection, 1893/19631
- J. Hoge Tyler Family Collection, 1802/19562
- James I. Robertson Jr. Papers, 1849/20111
- John Barnes Performing Arts Collection, 1890/1983, bulk 1940/19691
- John Janney Papers, 1811/1994, bulk 1840/18801
- Kammerer Family Business Collection, 1842/19141
- Kitchen Equipment Collection, 1847/20031