- Campbell Family Papers, 1843/19503
- Carleton Family Collection, 1830/19501
- Carter Newman Bealer Papers, 1905/1962, bulk 1930/19501
- Christopher A. Dorrance collection, 1750/20001
- Collection of U. S. House of Representatives printed documents about prohibition, 1808/19301
- Cralle and Hurt Family Papers, 1801/20053
- Davidson Family Papers, 1830/19153
- Dillon Family Papers, 1805/19444
- Douglass Family Papers, 1841/18471
- Dr. William S. Plumer manuscripts, 1841/18672
- Dunlap Family Papers, 1830/18784
- E. H. Simmons Receipts, 1847/18521
- Edson J. Harkness Papers, 1827/18651
- Elisha Franklin Paxton papers, 1808/1981, bulk 1853/18633
- Ellinor Porcher Gadsden Papers, 1839/19751