- Cocke Family Papers, 1725-1939494
- Southall Papers, 1807/1904393
- Galt Papers (I), 1745/1892122
- Carter Family Papers, 1667/1862, bulk 1792/1861100
- Tyler Family Papers, Group A, 1716/194688
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190079
- Tucker-Coleman papers, 1664/1945, bulk 1770/190773
- Webb-Prentis Family Papers
1770-190866
- Tyler Family Papers, Group D, 1939/195154
- Monongalia County (W. Va.) Court Records and Miscellaneous Papers, 1774/195448
- Papers relating to Edgar Allan Poe and John Henry Ingram's Poe collection, 1809/197039
- Haymond Family Papers, 1783/1867, bulk 1825/186732
- West Virginia Land Grants Records, 1748/191232
- Richard Kidder Randolph Family Papers
1791-193223
- Bound Music Collection, 1800/197021