- Southall Papers, 1807/1904653
- Cocke Family Papers, 1725-1939365
- Galt Papers (I), 1745/1892127
- Carter Family Papers, 1667/1862, bulk 1792/186197
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190079
- Tucker-Coleman papers, 1664/1945, bulk 1770/190779
- Webb-Prentis Family Papers
1770-190867
- Tyler Family Papers, Group D, 1939/195153
- Monongalia County (W. Va.) Court Records and Miscellaneous Papers, 1774/195448
- Haymond Family Papers, 1783/1867, bulk 1825/186733
- West Virginia Land Grants Records, 1748/191231
- Papers relating to Edgar Allan Poe and John Henry Ingram's Poe collection, 1809/197030
- Tyler Family Papers, Group G, 1645/191726
- Campbell Family Papers, 1726/192025
- Richard Kidder Randolph Family Papers
1791-193222