- Bell, Kent, Cloyd, Withrow Family Collection, 1780/199829
- John Janney Papers, 1811/1994, bulk 1840/188020
- Black, Kent, and Apperson Family Papers, 1779/198418
- Wharton and Radford Families Papers, 1783/190616
- Dillard-Larkin Family Papers, 1809/195513
- J. Hoge Tyler Family Collection, 1802/195611
- Smithfield Preston Foundation Papers, 1784/188111
- Pauline E. Burks Family Papers, 1763/198510
- Dickson Family Papers, 1769/19249
- Henry Iddings Family Collection, 1810/19007
- Stearns Family Papers, 1714/19207
- Bailey-Law Collection, 1825/19715
- Historical Maps Collection, 1500/20235
- Isaac Horne Ledgers, 1824/18705
- Martha L. Johnson Family Papers, 1821/18825