- Admiral John Randolph Tucker Papers, 1865/18972
- Alice Rice Jaffe Papers, 1807/1950, bulk 1919/19501
- Benjamin A. Banks Papers, 1855/19743
- Buck Family Papers, 1807/18501
- Calvert Walke Tazewell Papers, 1900/19971
- Cook Family Papers, 1872/19771
- Dean of the School of Business Administration Records, 1959/19771
- Elie Beatty Papers, 1814/18471
- Eloise Word Skewis Papers, 1777/19077
- Finlay Forbes Ferguson Papers, 1812/19753
- Harold S. Wilson Papers, 1813/19782
- Hodges Family Papers, 1754/197914
- James Washington Singleton Papers, 1770/1975, bulk 1850/192021
- Mason C. Andrews Papers, 1777/2010, bulk 1950/19906
- Nineteenth Century Stethoscope, 1800/18602