- E. H. Hook Diary, 1820/18712
- E. H. Moon ledger, 1830/18341
- Earhart Family Papers, 1788/19283
- Earl Gregg Swem Genealogy Collection, 1719/19825
- Earl L. Core (1902-1984) Papers, 1756/198516
- Easton-Avery Community History, 1769/19271
- Edgar E. MacDonald papers, 1933/19932
- Edith Moore Sprouse Papers (MS313), 1960/20031
- Edmonds Family Papers, 1790/18711
- Edmund J. Lee Papers, 1829/18492
- Edson J. Harkness Papers, 1827/18651
- Education Collection, 20171
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/1900104
- Edward Bland account book, 1806/18372
- Edward C. Dyer Papers, 1848/1865, bulk 1853/18655