- Ackerly Family Papers2
- Administration records collection, 1776/19764
- Alexander, Fultz, and Willson Families Collection, 1770/19701
- Alfred Leyburn Papers, 1823/1899, bulk 1830/18392
- Anderson Family papers, 1755/195824
- Ann Smith Academy Papers, 1807/19101
- Baer Family Papers, 1744/19291
- Bank of Rockbridge Currency and Lexington Lottery Ticket collection, 1803/18622
- Barbara Cary Johnston Willard Scrapbook, 1800/20061
- Ben Benson Collection, 1789/20151
- Board of Trustees records, 1774/19668
- Brady Family Papers, 1750/19801
- Carleton Family Collection, 1830/19501
- Christopher A. Dorrance collection, 1750/20001
- Collection of U. S. House of Representatives printed documents about prohibition, 1808/19301