- Armistead-Cocke Papers, 1680/19172
- Austin-Twyman Papers, 1765/19393
- Barker-Cooke Papers, 1809/1889, bulk 1848/18661
- Barron Family Papers, 1793/19422
- Barry S. Martin collection of historical manuscripts and documents, 1771/18301
- Benjamin Stoddert Ewell Papers, 1784/1934, bulk 1830/18921
- Betty Washington Lewis family papers, 1783/18441
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Board of Visitors records, 1757/20233
- Borland Family Papers, 1771/19402
- Broadside Collection, 1812/2013, bulk 1900/19501
- Brown, Coalter, Tucker Papers (I), 1790/19293
- Brown, Coalter, Tucker Papers (II), 1791/19202
- Bucktrout-Braithwaite Papers, 1780/1996, bulk 1890/18991
- Byers Family Papers, 1806/19292