- E. H. Hook Diary, 1820/18712
- Earhart Family Papers, 1788/19283
- Earl Gregg Swem Genealogy Collection, 1719/19826
- Earl L. Core (1902-1984) Papers, 1756/198515
- Easton-Avery Community History, 1769/19271
- Edgar E. MacDonald papers, 1933/19932
- Edith Moore Sprouse Papers (MS313), 1960/20031
- Edmonds Family Papers, 1790/18711
- Education Collection, 20171
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/1900102
- Edward Bland account book, 1806/18372
- Edward C. Dyer Papers, 1848/1865, bulk 1853/18653
- Edward Coles Papers [typescripts], 1814/18571
- Edward D. Bayles, Collector, Land Grants, 1791/18371
- Edward E. Meredith Papers, 1817/19541