- Saint Andrew's Society collection, 1861/19952
- Sale of slaves and land announcement, 18211
- Salt Sulphur Springs Records, 1819/19321
- Samuel B. Finley Account Books, 1802/18593
- Samuel E. Smith record book, 1818/18502
- Samuel G. Clark Liberty Iron Furnace Collection, 1809/19172
- Samuel H. Yonge papers, 1890/19351
- Samuel Henley Letter to Mr. Johnson, 1775/18001
- Samuel Myers Papers, 1796/1845, bulk 1820/18372
- Samuel Owings Hoffman Letters, 1821/18573
- Samuel Price, Lawyer and Politician, Papers, 1788/188811
- Samuel Vaughan Wilson Papers, 1945/20171
- Samuel Woodworth papers, 1818/18381
- Samuel and Bethel Morris Account Book, 1819-1835, 1819/1835, bulk 1819/18291
- Sarah Franklin Pike account book, 1821/18251