- Administration records collection, 1776/19761
- Anderson Family papers, 1755/195810
- Bank of Rockbridge Currency and Lexington Lottery Ticket collection, 1803/18621
- Board of Trustees records, 1774/196610
- Cralle and Hurt Family Papers, 1801/20051
- Dillon Family Papers, 1805/19442
- Draft will of Elijah Forsythe, 1800/18201
- Elisha Franklin Paxton papers, 1808/1981, bulk 1853/18631
- Franklin Society records, 1801/18916
- George A. Baxter Family papers, 1797/19188
- Graham Philanthropic Society records, 1809/19421
- Henry Ruffner collection, 1815/18674
- James Lewis Howe Papers, 1893/19511
- John C. Calhoun correspondence, 1818/18341
- Legal Documents, 1742/18951