- A.J. Morrison Collection, 1754/19751
- Account Book of Richard N. Venable, 1816/18211
- Account Books, 1782/18951
- Dr. John Peter Mettauer Papers, 1809/18591
- Family Bible of Jesse Michaux, 18191
- Hampden-Sydney Diploma Collection, 1775/19741
- J. D. Eggleston Papers, 1750/19521
- Manuscript: Book of Record of the Reids and Alexanders and Others by Jane Reid Venable, 1800/18341
- Paul L. Grier Vertical Files, 1775/19881
- Records of the Philanthropic, Union, and Union-Philanthropic Literary Societies, 1789/20071
- Sessional Records of South-Central Virginia Churches, 1760/19921