- T.T. Perry, Collector, Publications, 1806/18591
- Tabb Family Papers, 1797/18752
- Talbott-Tolbert Family Papers, 1784/19311
- Tate Thompson Brady Family papers, 1785/20052
- Taylor County Inns, Ledger Books, 1757/18871
- Taylor collection of Lewis family papers, 1700/19501
- Tazewell Family Papers, 1797/18502
- Tazewell Taylor Papers, 1784/18732
- Ted and Mary Wendell early American collection, 1721/18261
- Terrill-Porterfield Families, Papers regarding the Civil War and Other Material, 1716/1994, bulk 1840/19201
- The Cox-McPherson Ledgers and Papers
1758-1949 Inclusive1
- The Independent Collection, 1680/19601
- The Newcastle Memorandum book: Or, a Methodical Pocket-Journal, for the year 1764., 1764/18382
- The Reverend Dr. and Mrs. Richard Eugene Hager (Anne Peyton Judkins Hager) Collection, 1802/20071
- The Reverend Henry Gardiner Lane Memorial Collection, 1799/19382