- Saint Andrew's Society collection, 1861/19952
- Samuel B. Finley Account Books, 1802/18593
- Samuel H. Yonge papers, 1890/19351
- Samuel Hanway Papers, 1782/18181
- Samuel Henley Letter to Mr. Johnson, 1775/18001
- Samuel Myers Papers, 1796/1845, bulk 1820/18371
- Samuel Price, Lawyer and Politician, Papers, 1788/18889
- Samuel Vaughan Wilson Papers, 1945/20171
- Sarah Maria Everett Collection on James Madison, 18162
- Schoenbrun Collection of Virginia Historical Manuscripts, 1813/18951
- Scott Family Papers, 1793/19131
- Scott and Gunnell family papers, 1772/19902
- Scottish Court of Session records, 1757/183437
- Scrapbook, I, 1814/18731
- Sessional Records of South-Central Virginia Churches, 1760/19925