- Alexandria History Collection (MS240), 1767/20084
- Alexandria Library Company Records (MS002), 1794/20073
- Armistead Boothe Papers (MS164), 1803/19901
- Cazenove Family Papers (MS212), 1786/19704
- Edith Moore Sprouse Papers (MS313), 1960/20031
- Eleanor Lee Templeman Collection (MS061), 1810/19901
- Esther Holliday Green Collection (MS073), 1859/19824
- Ethelyn Cox Collection (MS287), 1956/19801
- John K. Pickens Papers (MS057), 1964/19762
- Milton Penn Collection (MS267), 1794/18932
- Penny C. Morrill Collection (MS104), 1970/19808
- Relief Truck and Engine Co. #1 Collection (MS130), 1788/19241
- Robert H. McNulty Papers (MS282), 1970/19912
- Shakes Letter Collection (MS005), 1778/20151
- Thomson Mason Papers (MS135), 1804/19123