- Earhart Family Papers, 1788/19283
- Earl Gregg Swem Genealogy Collection, 1719/19826
- Earl L. Core (1902-1984) Papers, 1756/198512
- Easton-Avery Community History, 1769/19271
- Edgar E. MacDonald papers, 1933/19931
- Edith Moore Sprouse Papers (MS313), 1960/20031
- Edmonds Family Papers, 1790/18711
- Edmund R. Custis Notebook, 1806/18081
- Education Collection, 20171
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/1900100
- Edward Bland account book, 1806/18372
- Edward D. Bayles, Collector, Land Grants, 1791/18371
- Edward N. Orr, Collector, Burch, Henshaw, and Neale Families Genealogy, 1806/19691
- Edwin W. Lynch Vietnam War protest collection, 1965/19753
- Eileen Peters, Compiler, Genealogy, 1887/199523