- B. J. Spruell Account Book, 1782/18362
- Baer Family Papers, 1744/19291
- Baird Family Papers, 1656/1922, bulk 1656/18482
- Baker Family Papers
1781-19218
- Baker Family Papers, 1805/19112
- Bakers' Guild Bylaws and Register (Harburg, Germany), 1668/18091
- Bane Family Genealogy, 1800/19551
- Bank of Rockbridge Currency and Lexington Lottery Ticket collection, 1803/18622
- Barbara Cary Johnston Willard Scrapbook, 1800/20061
- Barnes Family Papers, 1797/1926, bulk 1818/18751
- Barraud Family Papers, 1799/1904, bulk 1810/18602
- Barrett Minor Literary collection, 1802/19441
- Barron Family Papers, 1793/194212
- Barry S. Martin collection of historical manuscripts and documents, 1771/18302
- Baylor Family Papers
1653-19156