- Administration records collection, 1776/19761
- Alexander, Fultz, and Willson Families Collection, 1770/19701
- Anderson Family papers, 1755/19581
- Baer Family Papers, 1744/19291
- Bank of Rockbridge Currency and Lexington Lottery Ticket collection, 1803/18621
- Barbara Cary Johnston Willard Scrapbook, 1800/20061
- Ben Benson Collection, 1789/20151
- Board of Trustees records, 1774/19661
- Brady Family Papers, 1750/19801
- Christopher A. Dorrance collection, 1750/20001
- Cralle and Hurt Family Papers, 1801/20051
- Dillon Family Papers, 1805/19441
- Draft will of Elijah Forsythe, 1800/18201
- Duncan Green Campbell Papers, 1789/18251
- Francis P. Gaines Papers, 1803/19791