- Dickson Family Papers, 1769/192414
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/199813
- William Short Papers, 1785/19219
- Preston Family (Alice Preston Moore Collection) Papers, 1749/18827
- Wharton and Radford Families Papers, 1783/19067
- Pauline E. Burks Family Papers, 1763/19856
- Preston Family (Charles Peale Didier Collection) Papers, 1747/18976
- Stearns Family Papers, 1714/19205
- Historical Maps Collection, 1500/20234
- Charles W. Crush Collection, 1796/19783
- Earhart Family Papers, 1788/19283
- John Nicolay Papers, 1782/19833
- Marshall W. Fishwick Collection, 1700/2007, bulk 1923/20073
- Pauline Kirtley McPherson Collection, 1777/19923
- William Edward Foster Family Papers, 1820/19313