- Earhart Family Papers, 1788/19283
- Earl Gregg Swem Genealogy Collection, 1719/19825
- Earl L. Core (1902-1984) Papers, 1756/198510
- Easton-Avery Community History, 1769/19271
- Edgar E. MacDonald papers, 1933/19931
- Edith Moore Sprouse Papers (MS313), 1960/20031
- Edmonds Family Papers, 1790/18711
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190097
- Edward D. Bayles, Collector, Land Grants, 1791/18371
- Edward Vitale violin music collection, 1700/19001
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199523
- Elise S. Billmyer, Collector, Papers, 1636/19611
- Eliza H. Cocke Scrapbook, 1754/1823, bulk 18232
- Elizabeth Bordley Gibson collection, 1794/18517