- C. Harrison Mann, Jr. map collection, 1579/19613
- C. L. Worthington Papers, 1752/19384
- Cabell Family Papers, 1693/1913, bulk 1743/18236
- Calvert Walke Tazewell Papers, 1900/19971
- Campbell Family Papers, 1726/192014
- Caperton family genealogical research files, 1938/19803
- Carl R. Dolmetsch Papers, 1751/19902
- Carol R. Lubin papers, 1960/19811
- Carpenter Papers, 1765/19221
- Carr-Cary Family Papers
1785-18392
- Carrington Family Papers, 1785/18301
- Carrington Surveys, 1785/18121
- Carter Family Papers, 1667/1862, bulk 1792/186122
- Catesby Jones Account Book, 1767/18452
- Cazenove Family Papers (MS212), 1786/19709