- Blow Family Papers, 1613/1960, bulk 1770/18751
- Board of Visitors records, 1757/20232
- Borland Family Papers, 1771/19402
- Braxton County (W. Va.) Court Records and Miscellaneous Papers, 1830/19532
- Brooke County (W. Va.) Court Records and Miscellaneous Papers, 1780/19183
- Brown, Coalter, Tucker Papers (I), 1790/19292
- Brown, Coalter, Tucker Papers (II), 1791/19201
- Bucktrout-Braithwaite Papers, 1780/1996, bulk 1890/18991
- Bushrod Washington family papers, 1662/18353
- Cabell Family Papers, 1693/1913, bulk 1743/18232
- Calvert Walke Tazewell Papers, 1900/19971
- Carl R. Dolmetsch Papers, 1751/19901
- Carol R. Lubin papers, 1960/19812
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Cazenove Family Papers (MS212), 1786/19702