- Saint Andrew's Society collection, 1861/19952
- Samuel H. Yonge papers, 1890/19351
- Samuel Hanway Papers, 1782/18181
- Samuel Henley Letter to Mr. Johnson, 1775/18002
- Samuel Henley Papers, 1772/18042
- Samuel Price, Lawyer and Politician, Papers, 1788/18884
- Samuel Vaughan Wilson Papers, 1945/20171
- Sarah Anderson Jones Diary, 1792/17931
- Scott Family Papers, 1793/19132
- Scott and Gunnell family papers, 1772/19901
- Scottish Court of Session records, 1757/1834140
- Sessional Records of South-Central Virginia Churches, 1760/19923
- Seth Stowers Ledger, 1769/18112
- Shakes Letter Collection (MS005), 1778/20151
- Sheet Music Collection, 1827/19743