- D. Boston Stewart Papers, 1782/1919, bulk 1862/19061
- Daniel Morgan papers, 1788/18001
- David A. Bucher Papers, 1769/19126
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/18873
- David Merle Shingleton, Jr., Author, Shingleton Family Genealogy, 2010/20111
- Davidson Family Papers, 1773/19382
- Davis-Meranda Family of Clark County, Ohio, Genealogy, 1770/18501
- Deakins Family Papers and Surveying Compass, 1778/19251
- Deakins Family Papers, 1778/19251
- Dean of the School of Business Administration Records, 1959/19771
- Dickson Family Papers, 1769/192413
- Dille Family of Monongalia County (W.Va.), Financial, Legal, and Military Papers, 1785/1896, bulk 1816/18751
- Dismal Swamp Collection, 1763/19281
- Distiller's Ledger and Merchant's Ledger, 1779/18122
- Doddridge Family Manuscript, 1745/18571