- Alexandria History Collection (MS240), 1767/20088
- Alexandria, Virginia City Records (MS019), 1750/1983, bulk 1825/18751
- Cazenove Family Papers (MS212), 1786/19707
- Edith Moore Sprouse Papers (MS313), 1960/20031
- Esther Holliday Green Collection (MS073), 1859/19823
- Ethelyn Cox Collection (MS287), 1956/19801
- Helen Norris Cummings Papers (MS072), 1865/19491
- John Thomas Ricketts Papers (MS071), 1787/19041
- Kennedy-Barton Book Collection (MS277), 1753/18341
- Lyceum Construction Records (MS245), 1790/18591
- Penny C. Morrill Collection (MS104), 1970/19804
- Ramsay Family Papers Collection (MS012), 1742/19601
- Relief Truck and Engine Co. #1 Collection (MS130), 1788/19242
- Robert H. McNulty Papers (MS282), 1970/19911
- Shakes Letter Collection (MS005), 1778/20151