- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/18871
- David Merle Shingleton, Jr., Author, Shingleton Family Genealogy, 2010/20111
- Davidson Family Papers, 1773/19381
- Dean of the School of Business Administration Records, 1959/19771
- Dickson Family Papers, 1769/19241
- Distiller's Ledger and Merchant's Ledger, 1779/18121
- Don C. Miller Collection of Pine Forge Ledger, 1785/17991
- Donald M. Sweig Papers, 1976/1990, bulk 1976/19903
- Dorothy McCombs Collection,, 1970/19893
- Dunmore Family Papers (I) [in part photocopies], 1650/18992
- Earhart Family Papers, 1788/19281
- Earl Gregg Swem Genealogy Collection, 1719/19823
- Earl L. Core (1902-1984) Papers, 1756/19854
- Edgar E. MacDonald papers, 1933/19931
- Edith Moore Sprouse Papers (MS313), 1960/20031