- Bishop James Madison's preparatory notes on Smith's Wealth of Nations, 1776/18121
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18171
- Blow Family Papers, 1613/1960, bulk 1770/187532
- Board of Trustees records, 1774/19666
- Board of Visitors records, 1757/20232
- Bowman Family Papers, 1765/19981
- Brafferton Estate Collection, 1691/19352
- Bray Papers, 1730/18173
- Brown, Coalter, Tucker Papers (I), 1790/192910
- Bryan Family Papers, 1780/18251
- Bucktrout-Braithwaite Papers, 1780/1996, bulk 1890/18991
- C. L. Worthington Papers, 1752/19382
- Calvert Walke Tazewell Papers, 1900/19971
- Campbell Family Papers, 1726/19204
- Caperton family genealogical research files, 1938/19803