- Charles Brown Papers, 1792/18881
- Charles Campbell Papers, 1743/18963
- Clara L. Lawrence Papers, 1763/19391
- Coleman-Wilson Papers, 1775/1989, bulk 1883/19641
- David A. Bucher Papers, 1769/19121
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/18871
- Dickson Family Papers, 1769/19242
- Earhart Family Papers, 1788/19281
- Earl Gregg Swem Genealogy Collection, 1719/19821
- Earl L. Core (1902-1984) Papers, 1756/19852
- Eileen Peters, Compiler, Genealogy, 1887/19951
- Elizabeth Fairfax cookbook, 1694/17951
- Eloise Word Skewis Papers, 1777/19072
- Emory L. Kemp Papers regarding Industrial History, 1735/20212
- Esther Maria Lewis Chapin collection of Washington family documents, 1743/18522