- Alexander Balmaine Memorandum Book, 1775/18201
- Andrew Lindamood papers, 1768/18171
- Archibald Woods Papers, 1777/1846, bulk 1783/18461
- Armistead-Cocke Papers, 1680/19171
- Austin-Twyman Papers, 1765/19396
- Barraud Family Papers, 1799/1904, bulk 1810/18601
- Benjamin Layman Papers, 1752/18151
- Bishop James Madison Papers (Photostats), 1777/18121
- Bishop James Madison's preparatory notes on Smith's Wealth of Nations, 1776/18121
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18171
- Blow Family Papers, 1613/1960, bulk 1770/187519
- Board of Visitors records, 1757/20232
- Brafferton Estate Collection, 1691/19351
- Brainard Charlton Collection of Colonial and Continental Paper Money, 1775/17801
- Bray Papers, 1730/18173