- Carter Family Papers, 1667/1862, bulk 1792/186111
- Austin-Twyman Papers, 1765/19396
- Bushrod Washington family papers, 1662/18356
- Brown, Coalter, Tucker Papers (I), 1790/19295
- Dickson Family Papers, 1769/19245
- Jerdone Family papers, 1753/18904
- John Marshall Papers, 1755/18353
- Borland Family Papers, 1771/19402
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/19002
- Emory L. Kemp Papers regarding Industrial History, 1735/20212
- George Washington collection, 1654/17992
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19492
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/20111
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Earl L. Core (1902-1984) Papers, 1756/19851