- David A. Bucher Papers, 1769/19123
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/18873
- David Somervill Notebooks, 1768/17841
- David T. Rees, Collector, Orderly Book and Diary, 17781
- Davidson Family Papers, 1773/19382
- Davis-Meranda Family of Clark County, Ohio, Genealogy, 1770/18501
- Deakins Family Papers and Surveying Compass, 1778/19251
- Deakins Family Papers, 1778/19251
- Dean of the School of Business Administration Records, 1959/19771
- Deputy Quartermaster General for the Southern Department accounts of the Virginia Auditor of Public Accounts, 1776/17801
- Dickson Family Papers, 1769/192413
- Dismal Swamp Collection, 1763/19281
- Doddridge Family Manuscript, 1745/18571
- Donovan H. Bond, Compiler, Research Papers regarding Vandalia Colony and West Virginia Forts, 1962/2002, bulk 1756/19951
- Doris V. Welsh, Compiler, Varner and Darrah Families Papers, 1775/19181