- Armistead-Cocke Papers, 1680/19172
- Austin-Twyman Papers, 1765/19392
- Barron Family Papers, 1793/19421
- Barry S. Martin collection of historical manuscripts and documents, 1771/18303
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Board of Visitors records, 1757/20232
- Borland Family Papers, 1771/19401
- Brown, Coalter, Tucker Papers (I), 1790/19291
- Cabell Family Papers, 1693/1913, bulk 1743/18232
- Carl R. Dolmetsch Papers, 1751/19901
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Charles Brown Papers, 1792/18881
- Charles Campbell Papers, 1743/18963
- Clara L. Lawrence Papers, 1763/19391
- Coleman-Wilson Papers, 1775/1989, bulk 1883/19641