- David A. Bucher Papers, 1769/19123
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/18871
- David Somervill Notebooks, 1768/17841
- Davidson Family Papers, 1773/19382
- Davis-Meranda Family of Clark County, Ohio, Genealogy, 1770/18501
- Deputy Quartermaster General for the Southern Department accounts of the Virginia Auditor of Public Accounts,, 1776/17801
- Dickson Family Papers, 1769/192411
- Dismal Swamp Collection, 1763/19281
- Document regarding Indian Attacks in Pittsylvania County, Virginia, 17761
- Doddridge Family Manuscript, 1745/18571
- Donovan H. Bond, Compiler, Research Papers regarding Vandalia Colony and West Virginia Forts, 1962/2002, bulk 1756/19951
- Doris V. Welsh, Compiler, Varner and Darrah Families Papers, 1775/19181
- Dorothy McCombs Collection,, 1970/19891
- Duke Family Papers
1764-19831
- Dunmore Family Papers (I) [in part photocopies], 1650/18993